Functionalisation of artemisinin and its ring-contracted derivatives.

نویسندگان

  • Tine Van Neck
  • Sarah Van Mierloo
  • Wim Dehaen
چکیده

Isoxazoline analogues of artemisinin were obtained in low yield and low diastereoselectivity from the 1,3-dipolar cycloaddition of nitrile oxides. Alternatively, starting from the aldehyde 7, a number of transformations--Wittig reaction and reduction, Henry reaction and cyanohydrin formation--were achieved in significantly higher yields. In the cases where a new stereocenter was introduced this occurred diastereoselectively.

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عنوان ژورنال:
  • Molecules

دوره 12 3  شماره 

صفحات  -

تاریخ انتشار 2007